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For the most part, if you're in a happy and healthy relationship with someone much older or younger, that's your call, right?

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For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD? We provide estimated probabilities of onset associated with CAG repeats between 36 and 56 for individuals of any age with narrow confidence intervals. This model also defines the variability in HD onset that is not attributable to CAG length and provides information concerning CAG-related penetrance rates.

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Katherine Schwarzenegger31, married year-old " Avengers: Endgame " star Chris Pratt in a low-key ceremony on June 8, The two had been engaged since January and were reportedly dating for many months before that. The couple shared matching posts to their Instagram s after their wedding ceremony. Both called it "the best day of our lives" and said they feel "nothing but blessed.

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The couple welcomed their first child togethera daughter named Lyla Maria Schwarzenegger Pratt, in August The year-old singer and year-old actress made their first public appearance together ina year before they began dating. In an interview with Jimmy Kimmel, Chopra said that she and Jonas were both wearing Ralph Lauren to the Met Galaso they decided to attend the event together. She described the night as "fun," but didn't reveal much of anything else.

They married in December in multiple ceremonies.

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Reed32, and Somerhalder42, started their relationship in They were engaged in early and were married in April that same year. The couple welcomed daughter Bodhi Soleil in July Levine42, married Victoria's Secret model Prinsloo, 32, in Prinsloo gave birth to their first child, a daughter named Dusty Rose, in and their second daughter, Gio Grace, in Reynolds44, and Lively33, met and became friends while filming "Green Lantern" about a year before they officially started dating in They married in The happily married couple has three daughters: James, Ines, and a third child that was born in Their youngest child's name is believed to be named Betty, based on the lyrics of a song from Taylor Swifta close friend of the couple.

Vikander, 32, and Fassbender, 44, started dating after meeting on the set of "The Light Between Oceans.

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They have two daughters. Davis55, has been married to Tennon, 67, since The couple adopted a daughter in Tennon has two kids from relationships.

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Jackman52, and Lee-Furness, 65, have been together for more than 20 years, meeting on the set of Australian show "Correlli" and marrying in They've adopted two kids. They were married in August and had fraternal twinsCharlie and Poppy, in September Moyer has two other kids, Billy and Lilac, from a marriage.

McConaughey51, met model Alves39, in He proposed on Christmas inand the couple married in June They have three kids : sons Levi and Livingston and daughter Vida. Bomer43, and publicist Halls, 57, married in They have three sons. DeGeneres63, and de Rossi48, been together since and tied the knot in after the same-sex marriage ban in California was overturned. Hannah, 60, and Young, 75, got married in Young confirmed the news in November of that year when he shared a video online urging fans to vote and referred to Hannah as his "wife. They started dating in They have one son and a daughter.

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Model Klum, 47, started dating Tokio Hotel guitarist Kaulitz, 31, in Klum opened up to InStyle about how dating a man 17 years her junior makes people bring up age more. I don't really think about it that much otherwise.

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The couple got legally married in early and had a formal ceremony in Italy in August George, 59, met international human-rights lawyer Amal, 43, at a dinner party hosted by a mutual friend in The couple tied the knot in Italy in and welcomed twinsElla and Alexander, in June Murphy, 60, and Butcher, 41, have been together since and became engaged in The couple has two kids together, son Max and daughter Izzy.

Tamblyn, 37, married comedian Cross57, in The couple welcomed a daughter, Marlow, in Actor Statham53, and model-actress Huntington-Whiteley33, started dating in The couple got engaged in and welcomed their first childJack Oscar, in June The two actors were photographed holding hands in New York City in April and attended the LA premiere of "Marriage Story" in Novemberbut walked the red carpet separately.

46 celebrity couples with huge age differences between them

Pugh has repeatedly shut down comments from trolls on the internet regarding her age gap with the "Scrubs" star. Bening, 62, and Beatty, 84, met in while filming the gangster drama "Bugsy.

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Ford78, and Flockhart, 56, first met at the Golden Globe Awards. They married in and have an adopted son.

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Stallone, 74, and Flavin, 52, have been married since They first met inbut Stallone ended the relationship in after having an affair with Janice Dickinson. In a interview with Harper's Bazaarthe couple said that they were professional on the set of the movie. We had never been on a date, or even kissed. They got married in and changed their last name to Taylor-Johnson. The couple has two daughters, Wylda Rae and Romy Hero. Sam also has two daughters from a marriage.

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Willis, 66, married model Heming, 42, in They have two daughters: Mabel Ray and Evelyn Penn. In an interview after marrying, Willis said he fell in love with Heming after one date. DiCaprio, 45, has reportedly been dating model Morrone, 22, since December According to The Cut, they met at an event in Florida.

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Saget, 64, and TV host Rizzo, 41, married in Saget shared a photo on Instagram with the news. The couple announced their marriage with a post on Instagram that featured their dogs dressed as a bride and groom. They got engaged on Valentine's Day in Zeta-Jones51, and Douglas, 76, share the same birthday.

The celebrity couples with big age differences (guess which couple has an age gap of 39 years)

The two were introduced at the Deauville Film Festival inmarried in Novemberand have two kids. The couple briefly separated inbut are now back together. Alec63, married yoga instructor Hilaria37, in The couple has six children together. Cook, a year-old comedian, has a large age gap with the singer and fitness instructor. The couple has been dating since and flew to Hawaii for a romantic vacation in early In Februaryshe called him her "soulmate. After two years of being engaged, Roberts, 39, and Hasselhoff, 68, tied the knot in July Hasselhoff told OK!

Magazine that he did have some concerns about their age gap when they started dating.

40 celebrity couples with big age differences

Paulson confirmed their relationship in an interview with the New York Times in Goldblum68, married gymnast Livingston38, married in and have since had two sons, the second having ed the family in April The year-old Penn has been dating year-old George since Quaid, 67, got engaged to year-old PhD student Laura Savoie in The two had been dating for the past few months before getting engaged. They wed in The year-old model was photographed with year-old businessman Lewis in New York City in May Sincepeople have speculated that Spencer, who's the niece of Princess Di, was in a relationship with Lewis.

It was revealed in April that Gere, 71, and Silva, 38, secretly married "weeks and weeks ago," People confirmed. The two have been dating since They welcomed a son in February and Silva reportedly welcomed their second child in Foster, 70, and McPhee, 36, got engaged in while on an Italian vacation.

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They tied the knot in June and welcomed their first child together in Gibson, 65, and Ross, a year-old writer, welcomed a son in January They've been dating since around Stewart80, married jazz singer Ozell42, in after dating for roughly five years. Jagger, 77, and Hamrick, a year-old ballerina, have been together since They have a son named Deveraux. She shared an image on her Instagram of the two of them in Paris in and captioned the photo, "A dream with my love.